Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy

Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy

The Beta-adrenergic receptors (β-ARs) stimulation enhances contractility through protein kinase-A (PKA) substrate phosphorylation. This PKA signaling is conferred in part by PKA binding to A-kinase anchoring proteins (AKAPs). AKAPs coordinate multi-protein signaling networks that are targeted to spe...

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Bibliographic Details
Main Authors: Abeer Rababa'h, Sonal Singh, Santosh V. Suryavanshi, Salah Eldien Altarabsheh, Salil V. Deo, Bradley K. McConnell
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
hypertrophy
protein kinase A (PKA)
A kinase anchoring protein (AKAP)
contractility
Online Access:http://www.mdpi.com/1422-0067/16/1/218

Internet

http://www.mdpi.com/1422-0067/16/1/218

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