HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy

Abstract Background Cancer stem cells (CSCs) play a key role in cancer initiation, progression and chemoresistance. Epigenetic alterations have been identified as prominent factors that contribute to the CSCs phenotype. Here, we investigated the effects of the HDAC inhibitor valproic acid (VPA) and...

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Bibliographic Details
Main Authors: Marcella La Noce, Francesca Paino, Luigi Mele, Gianpaolo Papaccio, Tarik Regad, Angela Lombardi, Federica Papaccio, Vincenzo Desiderio, Virginia Tirino
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer stem cells
Osteosarcomas
Methylation
HDAC2
DNMT3a
Online Access:http://link.springer.com/article/10.1186/s13046-018-0978-x

Internet

http://link.springer.com/article/10.1186/s13046-018-0978-x

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