A Comparison of Blood Pathogen Detection Among Droplet Digital PCR, Metagenomic Next-Generation Sequencing, and Blood Culture in Critically Ill Patients With Suspected Bloodstream Infections

A Comparison of Blood Pathogen Detection Among Droplet Digital PCR, Metagenomic Next-Generation Sequencing, and Blood Culture in Critically Ill Patients With Suspected Bloodstream Infections

Metagenomic next-generation sequencing (mNGS) and droplet digital PCR (ddPCR) have recently demonstrated a great potential for pathogen detection. However, few studies have been undertaken to compare these two nucleic acid detection methods for identifying pathogens in patients with bloodstream infe...

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Bibliographic Details
Main Authors: Bangchuan Hu, Yue Tao, Ziqiang Shao, Yang Zheng, Run Zhang, Xuejing Yang, Jingquan Liu, Xi Li, Renhua Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Microbiology
Subjects:
droplet digital PCR
bloodstream infection
blood culture
pathogen
metagenomic next-generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.641202/full

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