Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy

• Main Authors: Poonam Yadav, Aleksandra Kuczmarska-Haas, Hima Bindu Musunuru, Jacob Witt, Grace Blitzer, Peter Mahler, Michael F. Bassetti
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Physics and Imaging in Radiation Oncology
• Subjects: Radiation induced liver damage; MRI-guided radiotherapy; SBRT
• Online Access: http://www.sciencedirect.com/science/article/pii/S2405631621000099
• ISSN: 2405-6316

This study reports dose corresponding to visible radiation induced liver damage following Stereotactic Body Radiation Therapy (SBRT) for liver metastasis, and the optimal time for follow up scans using post radiation imaging. Diagnostic magnetic resonance scans of nine patients treated with liver SBRT using a 0.35 T MRI-guided radiotherapy system were analyzed. The dice coefficients between the region of visible liver damage and the delivered dose were calculated. A median dose of 35 Gy correlated most closely with the visible radiation induced liver damage. We compared scans over two to nine months and observed maximal dice coefficients at two to five months post radiation. We have presented a new method for developing treatment planning guidelines for liver SBRT.