A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines

The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which...

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Main Authors:	Qianqian Zhang, Li Li, Bo Liu, Gang Liu
Format:	Article
Language:	English
Published:	MDPI AG 2013-05-01
Series:	Molecules
Subjects:	multi-component reaction heterocyclic compounds imidazo[4,5-g]-quinazoline structure determination hetero Diels-Alder reaction
Online Access:	http://www.mdpi.com/1420-3049/18/5/5697

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spelling	doaj-bb7d51ebb66a48a39cb3d24088eb66772020-11-25T02:39:30ZengMDPI AGMolecules1420-30492013-05-011855697570510.3390/molecules18055697A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolinesQianqian ZhangLi LiBo LiuGang LiuThe trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff’s base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation.http://www.mdpi.com/1420-3049/18/5/5697multi-component reactionheterocyclic compoundsimidazo[4,5-g]-quinazolinestructure determinationhetero Diels-Alder reaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qianqian Zhang Li Li Bo Liu Gang Liu
spellingShingle	Qianqian Zhang Li Li Bo Liu Gang Liu A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines Molecules multi-component reaction heterocyclic compounds imidazo[4,5-g]-quinazoline structure determination hetero Diels-Alder reaction
author_facet	Qianqian Zhang Li Li Bo Liu Gang Liu
author_sort	Qianqian Zhang
title	A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_short	A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_full	A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_fullStr	A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_full_unstemmed	A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_sort	novel multi-component reaction to imidazo[4,5-g]-quinazolines
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2013-05-01
description	The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff’s base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation.
topic	multi-component reaction heterocyclic compounds imidazo[4,5-g]-quinazoline structure determination hetero Diels-Alder reaction
url	http://www.mdpi.com/1420-3049/18/5/5697
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A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines

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