Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Abstract Background CD47, the integrin-related protein, plays an important role in immune resistance and escape of tumor cells. Antibodies blocking the CD47/SIRPα signal pathway can effectively stimulate macrophage-mediated phagocytosis of tumor cells, which becomes a promising approach for tumor im...

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Bibliographic Details
Main Authors: Linlin Ma, Min Zhu, Junwei Gai, Guanghui Li, Qing Chang, Peng Qiao, Longlong Cao, Wanqing Chen, Siyuan Zhang, Yakun Wan
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Nanobiotechnology
Subjects:
CD47
Immunotherapy
Nanobody
Bispecific antibody
Online Access:https://doi.org/10.1186/s12951-020-0571-2

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