What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics?

What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics?

Efforts to increase affinity in the design of new therapeutic molecules have tended to lead to greater lipophilicity, a factor that is generally agreed to be contributing to the low success rate of new drug candidates. Our aim is to provide a structural perspective to the study of lipophilic efficie...

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Bibliographic Details
Main Authors: Alicia P Higueruelo, Adrian Schreyer, G Richard J Bickerton, Tom L Blundell, Will R Pitt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3519888?pdf=render

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