CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation

CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation

We have recently generated knockout mice for the Cbx7 gene, coding for a polycomb group protein that is downregulated in human malignant neoplasias. These mice develop liver and lung adenomas and carcinomas, which confirms a tumour suppressor role for CBX7. The CBX7 ability to downregulate CCNE1 exp...

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Bibliographic Details
Main Authors: Floriana Forzati, Antonella Federico, Pierlorenzo Pallante, Marianna Colamaio, Francesco Esposito, Romina Sepe, Sara Gargiulo, Antonio Luciano, Claudio Arra, Giuseppe Palma, Giulia Bon, Stefania Bucher, Rita Falcioni, Arturo Brunetti, Sabrina Battista, Monica Fedele, Alfredo Fusco
Format: Article
Language:English
Published: The Company of Biologists 2014-09-01
Series:Biology Open
Subjects:
Cbx7
Adipose tissue
Mouse models
Online Access:http://bio.biologists.org/content/3/9/871

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