Quantifying the Role of Lysine in Prion Replication by Nano-LC Mass Spectrometry and Bioassay

Quantifying the Role of Lysine in Prion Replication by Nano-LC Mass Spectrometry and Bioassay

Prions propagate by a template driven process, inducing the normal cellular isoform (PrPC) to adopt the prion (PrPSc) conformation. In PrPC, the positions of lysines are highly conserved and strongly influence prion propagation. In this study, covalent modification was used to quantitate the role of...

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Bibliographic Details
Main Authors: Christopher J. Silva, Melissa L. Erickson-Beltran, Irina C. Dynin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
prion
mass spectrometry
Sc237
lysine
bioassay
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.562953/full

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