Hypoxia potentiates glioma-mediated immunosuppression.

Hypoxia potentiates glioma-mediated immunosuppression.

Glioblastoma multiforme (GBM) is a lethal cancer that exerts potent immune suppression. Hypoxia is a predominant feature of GBM, but it is unclear to the degree in which tumor hypoxia contributes to this tumor-mediated immunosuppression. Utilizing GBM associated cancer stem cells (gCSCs) as a treatm...

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Bibliographic Details
Main Authors: Jun Wei, Adam Wu, Ling-Yuan Kong, Yongtao Wang, Gregory Fuller, Isabella Fokt, Giovanni Melillo, Waldemar Priebe, Amy B Heimberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3024401?pdf=render

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