cfNOMe — A single assay for comprehensive epigenetic analyses of cell-free DNA

cfNOMe — A single assay for comprehensive epigenetic analyses of cell-free DNA

Abstract Cell-free DNA (cfDNA) analysis has become essential in cancer diagnostics and prenatal testing. We present cfNOMe, a two-in-one method of measuring cfDNA cytosine methylation and nucleosome occupancy in a single assay using non-disruptive enzymatic cytosine conversion and a custom bioinform...

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Bibliographic Details
Main Authors: Florian Erger, Deborah Nörling, Domenica Borchert, Esther Leenen, Sandra Habbig, Michael S. Wiesener, Malte P. Bartram, Andrea Wenzel, Christian Becker, Mohammad R. Toliat, Peter Nürnberg, Bodo B. Beck, Janine Altmüller
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Genome Medicine
Subjects:
cfNOMe
Cell-free DNA
Methylome
Nucleosome footprints
Analysis software
Online Access:http://link.springer.com/article/10.1186/s13073-020-00750-5

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