NG2 Proteoglycan Enhances Brain Tumor Progression by Promoting Beta-1 Integrin Activation in both Cis and Trans Orientations

NG2 Proteoglycan Enhances Brain Tumor Progression by Promoting Beta-1 Integrin Activation in both Cis and Trans Orientations

By physically interacting with beta-1 integrins, the NG2 proteoglycan enhances activation of the integrin heterodimers. In glioma cells, co-localization of NG2 and 31 integrin in individual cells (cis interaction) can be demonstrated by immunolabeling, and the NG2-integrin interaction can be confi...

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Bibliographic Details
Main Author: William B. Stallcup
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Cancers
Subjects:
brain tumor progression
brain tumor vascularization
NG2 proteoglycan
beta-1 integrin
pericyte
endothelial cell
macrophage
tumor vessel function
Cre-Lox gene ablation
Online Access:http://www.mdpi.com/2072-6694/9/4/31

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