Optimization of Early Steps in Oncolytic Adenovirus ONCOS-401 Production in T-175 and HYPERFlasks

Optimization of Early Steps in Oncolytic Adenovirus ONCOS-401 Production in T-175 and HYPERFlasks

Oncolytic adenoviruses can trigger lysis of tumor cells, induce an antitumor immune response, bypass classical chemotherapeutic resistance strategies of tumors, and provide opportunities for combination strategies. A major challenge is the development of scalable production methods for viral seed st...

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Bibliographic Details
Main Authors: Lukasz Kuryk, Anne-Sophie W Møller, Antti Vuolanto, Sari Pesonen, Mariangela Garofalo, Vincenzo Cerullo, Magnus Jaderberg
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
oncolytic adenovirus
CD40L
productivity
benzonase
manufacturing
optimization
cancer
MOI
harvesting time
virus productivity
Online Access:https://www.mdpi.com/1422-0067/20/3/621

Internet

https://www.mdpi.com/1422-0067/20/3/621

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