Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights

The gut microbiota plays a key role in cholesterol metabolism, mainly through the reduction of cholesterol to coprostanol. The latter sterol exhibits distinct physicochemical properties linked to its limited absorption in the gut. Few bacteria were reported to reduce cholesterol into coprostanol. Th...

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Main Authors:	Aicha Kriaa, Mélanie Bourgin, Héla Mkaouar, Amin Jablaoui, Nizar Akermi, Souha Soussou, Emmanuelle Maguin, Moez Rhimi
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Series:	Catalysts
Subjects:	cholesterol coprostanol reduction reaction bacteria metabolic pathways
Online Access:	https://www.mdpi.com/2073-4344/9/2/167

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record_format	Article
spelling	doaj-bb36c30758bb40d98be08ba190dbd63d2020-11-24T21:21:34ZengMDPI AGCatalysts2073-43442019-02-019216710.3390/catal9020167catal9020167Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New InsightsAicha Kriaa0Mélanie Bourgin1Héla Mkaouar2Amin Jablaoui3Nizar Akermi4Souha Soussou5Emmanuelle Maguin6Moez Rhimi7UMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceUMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceUMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceUMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceUMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceUMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceUMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceUMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, F-78350 Jouy-en-Josas, FranceThe gut microbiota plays a key role in cholesterol metabolism, mainly through the reduction of cholesterol to coprostanol. The latter sterol exhibits distinct physicochemical properties linked to its limited absorption in the gut. Few bacteria were reported to reduce cholesterol into coprostanol. Three microbial pathways of coprostanol production were described based on the analysis of reaction intermediates. However, these metabolic pathways and their associated genes remain poorly studied. In this review, we shed light on the microbial metabolic pathways related to coprostanol synthesis. Moreover, we highlight current strategies and future directions to better characterize these microbial enzymes and pathways.https://www.mdpi.com/2073-4344/9/2/167cholesterolcoprostanolreduction reactionbacteriametabolic pathways
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Aicha Kriaa Mélanie Bourgin Héla Mkaouar Amin Jablaoui Nizar Akermi Souha Soussou Emmanuelle Maguin Moez Rhimi
spellingShingle	Aicha Kriaa Mélanie Bourgin Héla Mkaouar Amin Jablaoui Nizar Akermi Souha Soussou Emmanuelle Maguin Moez Rhimi Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights Catalysts cholesterol coprostanol reduction reaction bacteria metabolic pathways
author_facet	Aicha Kriaa Mélanie Bourgin Héla Mkaouar Amin Jablaoui Nizar Akermi Souha Soussou Emmanuelle Maguin Moez Rhimi
author_sort	Aicha Kriaa
title	Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights
title_short	Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights
title_full	Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights
title_fullStr	Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights
title_full_unstemmed	Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights
title_sort	microbial reduction of cholesterol to coprostanol: an old concept and new insights
publisher	MDPI AG
series	Catalysts
issn	2073-4344
publishDate	2019-02-01
description	The gut microbiota plays a key role in cholesterol metabolism, mainly through the reduction of cholesterol to coprostanol. The latter sterol exhibits distinct physicochemical properties linked to its limited absorption in the gut. Few bacteria were reported to reduce cholesterol into coprostanol. Three microbial pathways of coprostanol production were described based on the analysis of reaction intermediates. However, these metabolic pathways and their associated genes remain poorly studied. In this review, we shed light on the microbial metabolic pathways related to coprostanol synthesis. Moreover, we highlight current strategies and future directions to better characterize these microbial enzymes and pathways.
topic	cholesterol coprostanol reduction reaction bacteria metabolic pathways
url	https://www.mdpi.com/2073-4344/9/2/167
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Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights

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