Enterovirus Transmission by Secretory Autophagy
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as...
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MDPI AG
2018-03-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/10/3/139 |
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doaj-bb302150d5f64e97b40bf855f443dd5d2020-11-24T23:10:16ZengMDPI AGViruses1999-49152018-03-0110313910.3390/v10030139v10030139Enterovirus Transmission by Secretory AutophagyYael Mutsafi0Nihal Altan-Bonnet1Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USALaboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USAPresent in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.http://www.mdpi.com/1999-4915/10/3/139secretory autophagypicornavirusenteroviruspoliovirusCoxsackievirusrhinovirussyntaxin 17viral transmissionquasispeciesRNA virus |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yael Mutsafi Nihal Altan-Bonnet |
| spellingShingle |
Yael Mutsafi Nihal Altan-Bonnet Enterovirus Transmission by Secretory Autophagy Viruses secretory autophagy picornavirus enterovirus poliovirus Coxsackievirus rhinovirus syntaxin 17 viral transmission quasispecies RNA virus |
| author_facet |
Yael Mutsafi Nihal Altan-Bonnet |
| author_sort |
Yael Mutsafi |
| title |
Enterovirus Transmission by Secretory Autophagy |
| title_short |
Enterovirus Transmission by Secretory Autophagy |
| title_full |
Enterovirus Transmission by Secretory Autophagy |
| title_fullStr |
Enterovirus Transmission by Secretory Autophagy |
| title_full_unstemmed |
Enterovirus Transmission by Secretory Autophagy |
| title_sort |
enterovirus transmission by secretory autophagy |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2018-03-01 |
| description |
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed. |
| topic |
secretory autophagy picornavirus enterovirus poliovirus Coxsackievirus rhinovirus syntaxin 17 viral transmission quasispecies RNA virus |
| url |
http://www.mdpi.com/1999-4915/10/3/139 |
| work_keys_str_mv |
AT yaelmutsafi enterovirustransmissionbysecretoryautophagy AT nihalaltanbonnet enterovirustransmissionbysecretoryautophagy |
| _version_ |
1725608007248642048 |