A computational approach for designing D-proteins with non-canonical amino acid optimised binding affinity.

Redesigning protein surface topology to improve target binding holds great promise in the search for highly selective therapeutics. While significant binding improvements can be achieved using natural amino acids, the introduction of non-canonical residues vastly increases sequence space and thus th...

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Bibliographic Details
Main Authors: Michael Garton, Maryam Sayadi, Philip M Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5673230?pdf=render

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