DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling.

DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling.

RIG-I-Like Receptors (RLRs) sense cytosolic viral RNA to transiently activate type I IFN production. Here, we report that a type I IFN inducible DExD/H helicase, DDX24, exerts a negative-regulatory effect on RLR function. Expression of DDX24 specifically suppressed RLR activity, while DDX24 loss, wh...

Full description

Bibliographic Details
Main Authors: Zhe Ma, Robert Moore, Xiangxi Xu, Glen N Barber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3814876?pdf=render

Similar Items

Similar Items