ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment

ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment

Immune checkpoint inhibitors (ICIs) have shown promising results in bladder cancer (BC). However, only some patients respond to ICIs. DNA repair defects (DDR) play an important role in the therapeutic response of bladder cancer. Therefore, we aimed to elucidate the association between ICIs in bladde...

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Bibliographic Details
Main Authors: Ruibin Yi, Anqi Lin, Manming Cao, Abai Xu, Peng Luo, Jian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Genetics
Subjects:
ATM
bladder cancer
immune checkpoint inhibitors
DDR
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00933/full

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