Genome evolution in yeast reveals connections between rare mutations in human cancers

Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutati...

Full description

Bibliographic Details
Main Authors:	Xinchen Teng, J. Marie Hardwick
Format:	Article
Language:	English
Published:	Shared Science Publishers OG 2014-06-01
Series:	Microbial Cell
Subjects:	yeast knockouts genome evolution secondary mutations cancer progression
Online Access:	http://microbialcell.com/researcharticles/genome-evolution-in-yeast-reveals-connections-between-rare-mutations-in-human-cancer/

id	doaj-bb05a5838100411f8bf58afef4a77581
record_format	Article
spelling	doaj-bb05a5838100411f8bf58afef4a775812020-11-24T22:54:34ZengShared Science Publishers OGMicrobial Cell2311-26382014-06-011620620910.15698/mic2014.06.153Genome evolution in yeast reveals connections between rare mutations in human cancersXinchen Teng0J. Marie Hardwick1College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, PRChina.W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 USA.Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.http://microbialcell.com/researcharticles/genome-evolution-in-yeast-reveals-connections-between-rare-mutations-in-human-cancer/yeast knockoutsgenome evolutionsecondary mutationscancer progression
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xinchen Teng J. Marie Hardwick
spellingShingle	Xinchen Teng J. Marie Hardwick Genome evolution in yeast reveals connections between rare mutations in human cancers Microbial Cell yeast knockouts genome evolution secondary mutations cancer progression
author_facet	Xinchen Teng J. Marie Hardwick
author_sort	Xinchen Teng
title	Genome evolution in yeast reveals connections between rare mutations in human cancers
title_short	Genome evolution in yeast reveals connections between rare mutations in human cancers
title_full	Genome evolution in yeast reveals connections between rare mutations in human cancers
title_fullStr	Genome evolution in yeast reveals connections between rare mutations in human cancers
title_full_unstemmed	Genome evolution in yeast reveals connections between rare mutations in human cancers
title_sort	genome evolution in yeast reveals connections between rare mutations in human cancers
publisher	Shared Science Publishers OG
series	Microbial Cell
issn	2311-2638
publishDate	2014-06-01
description	Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.
topic	yeast knockouts genome evolution secondary mutations cancer progression
url	http://microbialcell.com/researcharticles/genome-evolution-in-yeast-reveals-connections-between-rare-mutations-in-human-cancer/
work_keys_str_mv	AT xinchenteng genomeevolutioninyeastrevealsconnectionsbetweenraremutationsinhumancancers AT jmariehardwick genomeevolutioninyeastrevealsconnectionsbetweenraremutationsinhumancancers
_version_	1725659060875821056

Genome evolution in yeast reveals connections between rare mutations in human cancers

Similar Items