Effect of 5-aza-2'-deoxycytidine in comparison to valproic acid and trichostatin A on histone deacetylase 1, DNA methyltransferase 1, and CIP/KIP family (p21, p27, and p57) genes expression, cell growth inhibition, and apoptosis induction in colon cancer SW480 cell line

Effect of 5-aza-2'-deoxycytidine in comparison to valproic acid and trichostatin A on histone deacetylase 1, DNA methyltransferase 1, and CIP/KIP family (p21, p27, and p57) genes expression, cell growth inhibition, and apoptosis induction in colon cancer SW480 cell line

Background: Cancer initiation and progression depends on genetic and epigenetic alterations such as DNA methylation and histone modifications. Hypermethylation and deacetylation of the CIP/KIP family (p21, p27, and p57) lead to tumorigenesis. Our previous study indicated that DNA methyltransferase (...

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Bibliographic Details
Main Authors: Masumeh Sanaei, Fraidoon Kavoosi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Advanced Biomedical Research
Subjects:
5-Aza-2'-deoxycytidine
cancer
trichostatin A
valproic acid
Online Access:http://www.advbiores.net/article.asp?issn=2277-9175;year=2019;volume=8;issue=1;spage=52;epage=52;aulast=Sanaei

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