Genetic determination of the ovarian reserve: a literature review

• Main Authors: Aleksandra V. Moiseeva, Varvara A. Kudryavtseva, Vladimir N. Nikolenko, Marine M. Gevorgyan, Ara L. Unanyan, Anastassia A. Bakhmet, Mikhail Y. Sinelnikov
• Format: Article
• Language: English
• Published: BMC 2021-08-01
• Series: Journal of Ovarian Research
• Online Access: https://doi.org/10.1186/s13048-021-00850-9

Abstract The ovarian reserve is one of the most important indicators of female fertility. It allows for the evaluation of the number of viable oocytes. This parameter is actively used in pregnancy planning and in assisted reproductive technology application, as it determines chances of successful fertilization and healthy pregnancy. Due to increased attention towards diagnostic tests evaluating the ovarian reserve, there has been a growing interest in factors that influence the state of the ovarian reserve. True reasons for pathological changes in the ovarian reserve and volume have not yet been explored in depth, and current diagnostic screening methods often fall short in efficacy. In the following review we analyze existing data relating to the study of the ovarian reserve through genetic testing, determining specific characteristics of the ovarian reserve through genetic profiling. We explore existing studies dedicated to finding specific genetic targets influencing the state of the ovarian reserve.