Endometrial polyps with increased plasma cells are associated with chronic endometritis in infertility patients: Hysteroscopic findings and post‐polypectomy pregnancy rates

• Main Authors: Mari Nomiyama, Fumio Yamasaki, Mariko Tokunaga, Yukari Ohbuchi, Naka Sago, Kaoru Arima, Wakako Nishiyama, Mariko Hashiguchi, Kayoko Kojima
• Format: Article
• Language: English
• Published: Wiley 2021-10-01
• Series: Reproductive Medicine and Biology
• Subjects: endometritis; hysteroscopy; infertility; plasma cell; polyp
• Online Access: https://doi.org/10.1002/rmb2.12394
• ISSN: 1445-5781; 1447-0578

Abstract Purpose The relationship between endometrial polyps (EPs), chronic endometritis (CE), hysteroscopic findings, and antimicrobial in infertility patients was determined. Methods We retrospectively enrolled 115 infertility patients with suspected EPs who underwent office hysteroscopy. Patients were divided into 3 groups: 38 with increased plasma cells in EPs (group 1); 31 without increased plasma cells in EPs (group 2); and 46 without EPs (group 3). The 3 groups underwent hysteroscopy with or without polypectomies, and immediately thereafter, an endometrial aspiration biopsy (EAB) was performed. CE was diagnosed based on plasma cell infiltration in the non‐polypoid endometrium obtained by EAB. Results The percentage of CE was 68.4%, 32.2%, and 28.3% in groups 1, 2, and 3, respectively. CE was more frequent in group 1 than group 2 or 3 (P = .01 and P = .002, respectively). The number of polyps was higher in group 1 than group 2. After adjustment for age and assisted reproductive technology, antibiotic therapy was not associated with pregnancy (adjusted odds ratio, 0.44; 95% confidence interval, 0.05‐3.57) in patients with EPs and CE. Conclusions Group 1 was associated with CE, and hysteroscopic findings were different from group 2. Antibiotic therapy after polypectomy for EPs with CE may not always be necessary.