Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2

Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2

Abstract Background Hepatic stellate cell (HSC) activation is a central event during hepatic fibrosis. Aerobic glycolysis is one of its metabolic hallmarks. Blocking glycolysis is a novel therapeutic option for liver fibrosis. This study investigated the effects of costunolide, a natural product dem...

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Bibliographic Details
Main Authors: Dujing Ban, Shangbo Hua, Wen Zhang, Chao Shen, Xuehua Miao, Wensheng Liu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Hepatic fibrosis
Hepatic stellate cell
Costunolide
Glycolysis
Hexokinase 2
Online Access:http://link.springer.com/article/10.1186/s11658-019-0179-4

Internet

http://link.springer.com/article/10.1186/s11658-019-0179-4

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