MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma

MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma

A wide range of malignancies presents MYCN amplification (MNA) or dysregulation. MYCN is associated with poor prognosis and its over-expression leads to several dysregulations including metabolic reprogramming, mitochondria alteration, and cancer stem cell phenotype. Some hints suggest that MYCN ove...

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Bibliographic Details
Main Authors: Salvatore Raieli, Daniele Di Renzo, Silvia Lampis, Camilla Amadesi, Luca Montemurro, Andrea Pession, Patrizia Hrelia, Matthias Fischer, Roberto Tonelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
MYCN
immune system
neuroblastoma
immune signature
immune network
anti-MYCN antigene PNA
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.625207/full

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