Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters

Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters

The results presented herein represent our continued study based on the modification of phenolic functionality in molecules originated from natural sources by acylation. A small focused library of nineteen eugenyl esters, with four of which are new compounds, is reported. All compounds were subjecte...

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Main Authors: Jelena S Lazarević, Ana Kolarević, Gordana Stojanović, Andrija Šmelcerović, Pierangela Ciuffreda, Enzo Santaniello
Format: Article
Language:English
Published: Slovenian Chemical Society 2018-12-01
Series:Acta Chimica Slovenica
Subjects:
Chemical synthesis
eugenyl esters
in vitro antimicrobial activity
in silico calculation
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/4380
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spelling doaj-bacd4cf18c2b4c498220ae0e2d05ecbb2020-11-25T01:39:10ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552018-12-0165480181010.17344/acsi.2018.4380640Synthesis, Antimicrobial Activity and in silico Studies on Eugenol EtersJelena S Lazarević0Ana Kolarević1Gordana Stojanović2Andrija Šmelcerović3Pierangela Ciuffreda4Enzo Santaniello5Department of Chemistry, Faculty of Medicine, University of NišDepartment of Pharmacy, Faculty of Medicine, University of NišDepartment of Chemistry, Faculty of Science and Mathematics, University of NišDepartment of Chemistry, Faculty of Medicine, University of NišDipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di MilanoDepartment of Biomedical Sciences, Humanitas UniversityThe results presented herein represent our continued study based on the modification of phenolic functionality in molecules originated from natural sources by acylation. A small focused library of nineteen eugenyl esters, with four of which are new compounds, is reported. All compounds were subjected to in vitro antimicrobial testing. In silico studies were carried out calculating physico-chemical, pharmacokinetic and toxicological properties, providing more data as additional guidance for further research.https://journals.matheo.si/index.php/ACSi/article/view/4380Chemical synthesiseugenyl estersin vitro antimicrobial activityin silico calculation
collection DOAJ
language English
format Article
sources DOAJ
author Jelena S Lazarević
Ana Kolarević
Gordana Stojanović
Andrija Šmelcerović
Pierangela Ciuffreda
Enzo Santaniello
spellingShingle Jelena S Lazarević
Ana Kolarević
Gordana Stojanović
Andrija Šmelcerović
Pierangela Ciuffreda
Enzo Santaniello
Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters
Acta Chimica Slovenica
Chemical synthesis
eugenyl esters
in vitro antimicrobial activity
in silico calculation
author_facet Jelena S Lazarević
Ana Kolarević
Gordana Stojanović
Andrija Šmelcerović
Pierangela Ciuffreda
Enzo Santaniello
author_sort Jelena S Lazarević
title Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters
title_short Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters
title_full Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters
title_fullStr Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters
title_full_unstemmed Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters
title_sort synthesis, antimicrobial activity and in silico studies on eugenol eters
publisher Slovenian Chemical Society
series Acta Chimica Slovenica
issn 1318-0207
1580-3155
publishDate 2018-12-01
description The results presented herein represent our continued study based on the modification of phenolic functionality in molecules originated from natural sources by acylation. A small focused library of nineteen eugenyl esters, with four of which are new compounds, is reported. All compounds were subjected to in vitro antimicrobial testing. In silico studies were carried out calculating physico-chemical, pharmacokinetic and toxicological properties, providing more data as additional guidance for further research.
topic Chemical synthesis
eugenyl esters
in vitro antimicrobial activity
in silico calculation
url https://journals.matheo.si/index.php/ACSi/article/view/4380
work_keys_str_mv AT jelenaslazarevic synthesisantimicrobialactivityandinsilicostudiesoneugenoleters
AT anakolarevic synthesisantimicrobialactivityandinsilicostudiesoneugenoleters
AT gordanastojanovic synthesisantimicrobialactivityandinsilicostudiesoneugenoleters
AT andrijasmelcerovic synthesisantimicrobialactivityandinsilicostudiesoneugenoleters
AT pierangelaciuffreda synthesisantimicrobialactivityandinsilicostudiesoneugenoleters
AT enzosantaniello synthesisantimicrobialactivityandinsilicostudiesoneugenoleters
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