Modulation of peptidases by 2,4-diamine-quinazoline derivative induces cell death in the amitochondriate parasite Trichomonas vaginalis

Modulation of peptidases by 2,4-diamine-quinazoline derivative induces cell death in the amitochondriate parasite Trichomonas vaginalis

Trichomonas vaginalis is an amitochondriate protozoan and the agent of human trichomoniasis, the most prevalent non-viral sexually transmitted infection (STI) in the world. In this study we showed that 2,4-diamine-quinazoline derivative compound (PH100) kills T. vaginalis. PH100 showed activity agai...

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Bibliographic Details
Main Authors: Juliana Inês Weber, Graziela Vargas Rigo, Débora Assumpção Rocha, Isadora Serraglio Fortes, Adriana Seixas, Saulo Fernandes de Andrade, Tiana Tasca
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Trichomonas vaginalis
Amitochondriate
Quinazoline
Cell death
Peptidases
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221003966

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http://www.sciencedirect.com/science/article/pii/S0753332221003966

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