A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice

A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Leprdb/db mice

The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure, and body weight. Mutations in leptin and the Lepr have been shown to cause early-onset severe obesity in mice and humans. In studies with C57BL/6NCrl mice, we found a mouse with extreme obesity. To identi...

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Bibliographic Details
Main Authors: Claudia Berger, Henrike O. Heyne, Tina Heiland, Sebastian Dommel, Corinna Höfling, Esther Guiu-Jurado, Jana Lorenz, Steffen Roßner, Michael Dannemann, Janet Kelso, Peter Kovacs, Matthias Blüher, Nora Klöting
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
Lepr
leptin receptor mutation
obesity
compound heterozygous
genetic background
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521000870

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