The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism

Among the myriad of molecules produced by the liver, both bile acids and their precursors, the oxysterols are becoming pivotal bioactive lipids which have been underestimated for a long time. Their actions are ranging from regulation of energy homeostasis (i.e., glucose and lipid metabolism) to infl...

Full description

Bibliographic Details
Main Authors:	Charlotte Lefort, Patrice D. Cani
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Cells
Subjects:	liver bile acids oxysterols inflammation gut microbiota steatosis
Online Access:	https://www.mdpi.com/2073-4409/10/2/400

id	doaj-bac2946c73904a41a001391060a79e9b
record_format	Article
spelling	doaj-bac2946c73904a41a001391060a79e9b2021-02-17T00:00:29ZengMDPI AGCells2073-44092021-02-011040040010.3390/cells10020400The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling MetabolismCharlotte Lefort0Patrice D. Cani1Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Brussels, BelgiumMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Brussels, BelgiumAmong the myriad of molecules produced by the liver, both bile acids and their precursors, the oxysterols are becoming pivotal bioactive lipids which have been underestimated for a long time. Their actions are ranging from regulation of energy homeostasis (i.e., glucose and lipid metabolism) to inflammation and immunity, thereby opening the avenue to new treatments to tackle metabolic disorders associated with obesity (e.g., type 2 diabetes and hepatic steatosis) and inflammatory diseases. Here, we review the biosynthesis of these endocrine factors including their interconnection with the gut microbiota and their impact on host homeostasis as well as their attractive potential for the development of therapeutic strategies for metabolic disorders.https://www.mdpi.com/2073-4409/10/2/400liverbile acidsoxysterolsinflammationgut microbiotasteatosis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Charlotte Lefort Patrice D. Cani
spellingShingle	Charlotte Lefort Patrice D. Cani The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism Cells liver bile acids oxysterols inflammation gut microbiota steatosis
author_facet	Charlotte Lefort Patrice D. Cani
author_sort	Charlotte Lefort
title	The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism
title_short	The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism
title_full	The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism
title_fullStr	The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism
title_full_unstemmed	The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism
title_sort	liver under the spotlight: bile acids and oxysterols as pivotal actors controlling metabolism
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2021-02-01
description	Among the myriad of molecules produced by the liver, both bile acids and their precursors, the oxysterols are becoming pivotal bioactive lipids which have been underestimated for a long time. Their actions are ranging from regulation of energy homeostasis (i.e., glucose and lipid metabolism) to inflammation and immunity, thereby opening the avenue to new treatments to tackle metabolic disorders associated with obesity (e.g., type 2 diabetes and hepatic steatosis) and inflammatory diseases. Here, we review the biosynthesis of these endocrine factors including their interconnection with the gut microbiota and their impact on host homeostasis as well as their attractive potential for the development of therapeutic strategies for metabolic disorders.
topic	liver bile acids oxysterols inflammation gut microbiota steatosis
url	https://www.mdpi.com/2073-4409/10/2/400
work_keys_str_mv	AT charlottelefort theliverunderthespotlightbileacidsandoxysterolsaspivotalactorscontrollingmetabolism AT patricedcani theliverunderthespotlightbileacidsandoxysterolsaspivotalactorscontrollingmetabolism AT charlottelefort liverunderthespotlightbileacidsandoxysterolsaspivotalactorscontrollingmetabolism AT patricedcani liverunderthespotlightbileacidsandoxysterolsaspivotalactorscontrollingmetabolism
_version_	1724265938552881152

The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism

Similar Items