Decreased Neurofilament L Chain Levels in Cerebrospinal Fluid and Tolerogenic Plasmacytoid Dendritic Cells in Natalizumab-Treated Multiple Sclerosis Patients – Brief Research Report

Decreased Neurofilament L Chain Levels in Cerebrospinal Fluid and Tolerogenic Plasmacytoid Dendritic Cells in Natalizumab-Treated Multiple Sclerosis Patients – Brief Research Report

BackgroundNeurofilament Light (NfL) chain levels in both cerebrospinal fluid (CSF) and serum have been correlated with the reduction of axonal damage in multiple sclerosis (MS) patients treated with Natalizumab (NTZ). However, little is known about the function of plasmacytoid cells in NTZ-treated M...

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Main Authors: Adriel S. Moraes, Vinicius O. Boldrini, Alliny C. Dionete, Marilia D. Andrade, Ana Leda F. Longhini, Irene Santos, Amanda D. R. Lima, Veronica A. P. G. Silva, Rafael P. C. Dias Carneiro, Raphael P. S. Quintiliano, Breno B. Ferrari, Alfredo Damasceno, Fernando Pradella, Alessandro S. Farias, Charles P. Tilbery, Renan B. Domingues, Carlos Senne, Gustavo B. P. Fernandes, Felipe von Glehn, Carlos Otavio Brandão, Carla R. A. V. Stella, Leonilda M. B. Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuroinflammation
HLA-DR
HLA-G
PD-L1
neurofilament light chain
cerebrospinal fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.705618/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.705618/full

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