Phenotypic Characterization of Immortalized Chondrocytes from a Desbuquois Dysplasia Type 1 Mouse Model: A Tool for Studying Defects in Glycosaminoglycan Biosynthesis

Phenotypic Characterization of Immortalized Chondrocytes from a Desbuquois Dysplasia Type 1 Mouse Model: A Tool for Studying Defects in Glycosaminoglycan Biosynthesis

The complexity of skeletal pathologies makes use of in vivo models essential to elucidate the pathogenesis of the diseases; nevertheless, chondrocyte and osteoblast cell lines provide relevant information on the underlying disease mechanisms. Due to the limitations of primary chondrocytes, immortali...

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Bibliographic Details
Main Authors: Chiara Gramegna Tota, Beatrice Valenti, Antonella Forlino, Antonio Rossi, Chiara Paganini
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
proteoglycan
collagen
cartilage
extracellular matrix
in vitro model
immortalization
Online Access:https://www.mdpi.com/1422-0067/22/17/9304

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