THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS

THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS

The paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to t...

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Bibliographic Details
Main Authors: A. A. Alikhanov, N. L. Shimanovskiy
Format: Article
Language:English
Published: LUCHEVAYA DIAGNOSTIKA, LLC 2017-05-01
Series:Вестник рентгенологии и радиологии
Subjects:
review
magnetic resonance imaging
contrast-enhanced
gadobutrol
neonates
babies
pharmacokinetics
macrocyclic compaund
Online Access:https://www.russianradiology.ru/jour/article/view/210
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spelling doaj-ba91609b1f8946109684b9a4ba2f45302021-09-15T15:32:23ZengLUCHEVAYA DIAGNOSTIKA, LLCВестник рентгенологии и радиологии0042-46762619-04782017-05-019829710210.20862/0042-4676-2017-98-2-97-102171THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTSA. A. Alikhanov0N. L. Shimanovskiy1Russian State Children Hospital, Ministry of Health of the RFPirogov Russian National Research Medical University, Ministry of Health of the RFThe paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to that in older children and adults. Gadobutrol given at a standard dose of 0.1 mmol/kg body weight has a favorable safety profile and is well tolerated by children of any age and by adults. There is evidence that the use of gadobutrol may be extrapolated to infants younger than 2 years of age, including full-term neonates, for the effective diagnosis of blood-brain barrier disorders, pathological changes in the cardiovascular system, and focal diseases of the internal organs of the whole body.https://www.russianradiology.ru/jour/article/view/210reviewmagnetic resonance imagingcontrast-enhancedgadobutrolneonatesbabiespharmacokineticsmacrocyclic compaund
collection DOAJ
language English
format Article
sources DOAJ
author A. A. Alikhanov
N. L. Shimanovskiy
spellingShingle A. A. Alikhanov
N. L. Shimanovskiy
THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
Вестник рентгенологии и радиологии
review
magnetic resonance imaging
contrast-enhanced
gadobutrol
neonates
babies
pharmacokinetics
macrocyclic compaund
author_facet A. A. Alikhanov
N. L. Shimanovskiy
author_sort A. A. Alikhanov
title THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
title_short THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
title_full THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
title_fullStr THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
title_full_unstemmed THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
title_sort diagnostic efficacy, safety and bioequivalence of gadobutrol used in infants aged less than 2 years compared with older children and adults
publisher LUCHEVAYA DIAGNOSTIKA, LLC
series Вестник рентгенологии и радиологии
issn 0042-4676
2619-0478
publishDate 2017-05-01
description The paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to that in older children and adults. Gadobutrol given at a standard dose of 0.1 mmol/kg body weight has a favorable safety profile and is well tolerated by children of any age and by adults. There is evidence that the use of gadobutrol may be extrapolated to infants younger than 2 years of age, including full-term neonates, for the effective diagnosis of blood-brain barrier disorders, pathological changes in the cardiovascular system, and focal diseases of the internal organs of the whole body.
topic review
magnetic resonance imaging
contrast-enhanced
gadobutrol
neonates
babies
pharmacokinetics
macrocyclic compaund
url https://www.russianradiology.ru/jour/article/view/210
work_keys_str_mv AT aaalikhanov thediagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults
AT nlshimanovskiy thediagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults
AT aaalikhanov diagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults
AT nlshimanovskiy diagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults
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