CURRENT PROGRESS IN STRUCTURE-BASED RATIONAL DRUG DESIGN MARKS A NEW MINDSET IN DRUG DISCOVERY

CURRENT PROGRESS IN STRUCTURE-BASED RATIONAL DRUG DESIGN MARKS A NEW MINDSET IN DRUG DISCOVERY

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The past decade has witnessed a paradigm shift in preclinical drug discovery with structure-based drug design (SBDD) making a comeback while high-throughput screening (HTS) methods have continued to generate disappointing results. There is a deficit of information between identified hits and the man...

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Bibliographic Details
Main Authors: Valère Lounnas, Tina Ritschel, Jan Kelder, Ross McGuire, Robert P. Bywater, Nicolas Foloppe
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Rational drug design
virtual screening
protein kinase
G-protein coupled receptors
ligand binding thermodynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014600398

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http://www.sciencedirect.com/science/article/pii/S2001037014600398

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