Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection.

Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection.

Cytosolic fungal fatty acid synthase is composed of two subunits alpha and beta, which are encoded by Fas1 and Fas2 genes. In this study, the Fas2 genes of the human pathogen Candida parapsilosis were deleted using a modified SAT1 flipper technique. CpFas2 was essential in media lacking exogenous fa...

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Bibliographic Details
Main Authors: Long Nam Nguyen, David Trofa, Joshua D Nosanchuk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2791871?pdf=render

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