Paradoxical effects of all-trans-retinoic acid on lupus-like disease in the MRL/lpr mouse model.

Paradoxical effects of all-trans-retinoic acid on lupus-like disease in the MRL/lpr mouse model.

Roles of all-trans-retinoic acid (tRA), a metabolite of vitamin A (VA), in both tolerogenic and immunogenic responses are documented. However, how tRA affects the development of systemic autoimmunity is poorly understood. Here we demonstrate that tRA have paradoxical effects on the development of au...

Full description

Bibliographic Details
Main Authors: Xiaofeng Liao, Jingjing Ren, Cheng-Hsin Wei, A Catharine Ross, Thomas E Cecere, Bernard S Jortner, S Ansar Ahmed, Xin M Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4361690?pdf=render

Internet

http://europepmc.org/articles/PMC4361690?pdf=render

Similar Items