Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their...

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Main Authors: Xuehui Fan, Tianyi Sun, William Crawford, Xiaoqiu Tan, Xianhong Ou, Derek A. Terrar, Steven N. Ebert, Ming Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Physiology
Subjects:
optogenetics
Pnmt-derived cardiomyocytes
heart
Pnmt
catecholamines
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00713/full
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spelling doaj-ba72eceea47d4f87bc2679704990f26f2020-11-25T00:16:16ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-07-011010.3389/fphys.2019.00713441706Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future PerspectivesXuehui Fan0Tianyi Sun1William Crawford2Xiaoqiu Tan3Xianhong Ou4Derek A. Terrar5Steven N. Ebert6Ming Lei7Ming Lei8Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacology, University of Oxford, Oxford, United KingdomDepartment of Pharmacology, University of Oxford, Oxford, United KingdomKey Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, ChinaKey Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacology, University of Oxford, Oxford, United KingdomBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, United StatesKey Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention of Cardiovascular Diseases, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacology, University of Oxford, Oxford, United KingdomIn this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca2+ transient properties, and potential role in localized adrenergic signaling are discussed.https://www.frontiersin.org/article/10.3389/fphys.2019.00713/fulloptogeneticsPnmt-derived cardiomyocytesheartPnmtcatecholamines
collection DOAJ
language English
format Article
sources DOAJ
author Xuehui Fan
Tianyi Sun
William Crawford
Xiaoqiu Tan
Xianhong Ou
Derek A. Terrar
Steven N. Ebert
Ming Lei
Ming Lei
spellingShingle Xuehui Fan
Tianyi Sun
William Crawford
Xiaoqiu Tan
Xianhong Ou
Derek A. Terrar
Steven N. Ebert
Ming Lei
Ming Lei
Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
Frontiers in Physiology
optogenetics
Pnmt-derived cardiomyocytes
heart
Pnmt
catecholamines
author_facet Xuehui Fan
Tianyi Sun
William Crawford
Xiaoqiu Tan
Xianhong Ou
Derek A. Terrar
Steven N. Ebert
Ming Lei
Ming Lei
author_sort Xuehui Fan
title Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_short Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_full Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_fullStr Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_full_unstemmed Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives
title_sort pnmt-derived cardiomyocytes: anatomical localization, function and future perspectives
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2019-07-01
description In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca2+ transient properties, and potential role in localized adrenergic signaling are discussed.
topic optogenetics
Pnmt-derived cardiomyocytes
heart
Pnmt
catecholamines
url https://www.frontiersin.org/article/10.3389/fphys.2019.00713/full
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AT tianyisun pnmtderivedcardiomyocytesanatomicallocalizationfunctionandfutureperspectives
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AT xianhongou pnmtderivedcardiomyocytesanatomicallocalizationfunctionandfutureperspectives
AT derekaterrar pnmtderivedcardiomyocytesanatomicallocalizationfunctionandfutureperspectives
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