Inflammatory markers mediated diabetic nephropathy in patients with type 1 and type 2 diabetes mellitus

• Main Authors: Madha M. Sheet Saleh, Ghuroob D. Dhamad, Laith Abul-Ellah Kamel
• Format: Article
• Language: English
• Published: Faculty of Medicine University of Baghdad 2015-01-01
• Series: مجلة كلية الطب
• Subjects: Diabetic nephropathy, interleukin-18, tumor necrotic factor-alpha.
• Online Access: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/556
• ISSN: 0041-9419; 2410-8057

Background: Diabetic nephropathy (DN) represents the most common cause of end stage renal disease (ESRD) worldwide. Diabetic nephropathy occurs as a result of an interaction between hemodynamic and metabolic factors, however recent evidence shows an increase growing support for the notion that inflammation plays a key role in the pathogenesis of diabetic nephropathy. Objectives: To speculate the role of IL-18 and TNF-α proinflammatory cytokines in the initiation and development of diabetic nephropathy in T1DM and T2DM. Materials and methods: Eighty seven T1DM and T2DM patients with or without DN were enrolled. IL-18 and TNF-α cytokines were measured by solid phase immunosorbent assays. Materials and methods: Eighty seven T1DM and T2DM patients with or without DN were enrolled. IL-18 and TNF-α cytokines were measured by solid phase immunosorbent assays. Results: IL-18 had increased significantly in patients with DN compared to those without DN in T1DM and T2DM patients whereas TNF-α had exhibited a significant elevation among patients with DN compared to those without DN in T2DM but not T1DM. Conclusion: IL-18 is suggested to play a crucial role in the initiation, development, and progression of DN in T1DM and T2DM patients whereas TNF-α is playing a similar role but only in T1DM patients with DN.