Suppression of FVIII-Specific Memory B Cells by Chimeric BAR Receptor-Engineered Natural Regulatory T Cells

Suppression of FVIII-Specific Memory B Cells by Chimeric BAR Receptor-Engineered Natural Regulatory T Cells

Anti-drug antibody formation poses tremendous obstacles for optimal treatment of hemophilia A (HA). In this study, we sought to utilize chimeric receptor-modified natural regulatory T cells (Tregs) to target FVIII-specific memory B cells, which are responsible for persistent anti-FVIII neutralizing...

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Bibliographic Details
Main Authors: Alessandra De Paula Pohl, Shivaprasad H. Venkatesha, Ai-Hong Zhang, David W. Scott
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
FVIII
memory B cells
regulatory T cells
chimeric receptor
B-cell antibody receptor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00693/full

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