Synthesis and Biological Evaluation of Novel 4-(4-Formamidophenylamino)-<i>N</i>-methylpicolinamide Derivatives as Potential Antitumor Agents

Synthesis and Biological Evaluation of Novel 4-(4-Formamidophenylamino)-<i>N</i>-methylpicolinamide Derivatives as Potential Antitumor Agents

A novel series of 4-(4-formamidophenylamino)-<i>N</i>-methylpicolinamide derivatives were synthesized and evaluated against different tumor cell lines. Experiments in vitro showed that these derivatives could inhibit the proliferation of two kinds of human cancer cell lines (HepG2, HCT11...

Full description

Bibliographic Details
Main Authors:	Nana Meng, Shuyan Zhou, Min Hu, Youzhi Xu, Yong Xia, Xiuxiu Zeng, Luoting Yu
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Molecules
Subjects:	4-(4-formamidophenylamino)-<i>N</i>-methylpicolinamide derivatives anti-proliferation angiogenesis inhibitors apoptosis pharmacology
Online Access:	https://www.mdpi.com/1420-3049/26/4/1150

Similar Items

Synthesis and Biological Evaluation of Novel <em>N</em>-Methyl-picolinamide-4-thiol Derivatives as Potential Antitumor Agents
by: Luo-Ting Yu, et al.
Published: (2012-05-01)

MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (<i>Channa argus</i>)
by: Zheng-Yong Wen, et al.
Published: (2021-03-01)

Association of <i>IL-4</i> and <i>IL-4R</i> Polymorphisms with Litter Size Traits in Pigs
by: Worrarak Norseeda, et al.
Published: (2021-04-01)

Efficient Regioselective Synthesis of Novel Water-Soluble 2<i>H</i>,3<i>H</i>-[1,4]thiazino[2,3,4-<i>ij</i>]quinolin-4-ium Derivatives by Annulation Reactions of 8-quinolinesulfenyl Halides
by: Vladimir A. Potapov, et al.
Published: (2021-02-01)

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and <i>C</i>-5a-Substituted Derivatives of 4-<i>epi</i>-Isofagomine
by: Patrick Weber, et al.
Published: (2020-09-01)

Auxin-Induced <i>SaARF4</i> Downregulates <i>SaACO4</i> to Inhibit Lateral Root Formation in <i>Sedum alfredii</i> Hance
by: Dong Xu, et al.
Published: (2021-01-01)

The Emerging Role of Inhibitor of Growth 4 as a Tumor Suppressor in Multiple Human Cancers
by: Shiyun Cui, et al.
Published: (2015-05-01)

4<i>H</i>-Benzo[<i>d</i>][1,3]oxazin-4-ones and Dihydro Analogs from Substituted Anthranilic Acids and Orthoesters
by: Joel K. Annor-Gyamfi, et al.
Published: (2019-10-01)

Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling
by: Fuqing Hu, et al.
Published: (2018-07-01)

A Novel Family of [1,4]Thiazino[2,3,4-<i>ij</i>]quinolin-4-ium Derivatives: Regioselective Synthesis Based on Unsaturated Heteroatom and Heterocyclic Compounds and Antibacterial Activity
by: Vladimir A. Potapov, et al.
Published: (2021-09-01)

Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
by: Guangjin Yu, et al.
Published: (2014-06-01)

The role of semaphorin 4D in tumor development and angiogenesis in human breast cancer
by: Jiang HC, et al.
Published: (2016-09-01)

4-[4-(3-Methoxybenzamido)phenoxy]-N-methylpicolinamide
by: Na-Na Meng, et al.
Published: (2010-02-01)

Protective Effects of Flavone from <i>Tamarix aphylla</i> against CCl<sub>4</sub>-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis
by: Bishoy El-Aarag, et al.
Published: (2019-10-01)

FGF19–<i>FGFR4</i> Signaling in Hepatocellular Carcinoma
by: Aroosha Raja, et al.
Published: (2019-06-01)

<i>N′</i>-Acetyl-3-methyl-1,6-diphenyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine-4-carbohydrazide
by: Júlio C. A. V. Soares, et al.
Published: (2020-01-01)

Chloroplastic <i>SaNADP-ME4</i> of C<sub>3</sub>–C<sub>4</sub> Woody Desert Species <i>Salsola laricifolia</i> Confers Drought and Salt Stress Resistance to <i>Arabidopsis</i>
by: Zhibin Wen, et al.
Published: (2021-09-01)

An Overview of the Genetics of <i>ABCA4</i> Retinopathies, an Evolving Story
by: Saoud Al-Khuzaei, et al.
Published: (2021-08-01)

A 60% Edible Ethanolic Extract of <i>Ulmus davidiana</i> Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis
by: Jeongho Park, et al.
Published: (2021-02-01)

Genome Sequencing of the Japanese Eel (<i>Anguilla japonica</i>) for Comparative Genomic Studies on <i>tbx4</i> and a <i>tbx4</i> Gene Cluster in Teleost Fishes
by: Weiwei Chen, et al.
Published: (2019-07-01)

Quinazolin-4(3<i>H</i>)-ones and 5,6-Dihydropyrimidin-4(3<i>H</i>)-ones from β-Aminoamides and Orthoesters
by: Joshua T. Gavin, et al.
Published: (2018-11-01)

An Exo-Polygalacturonase Pgc4 Regulates Aerial Hyphal Growth and Virulence in <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> race 4
by: Zhangyong Dong, et al.
Published: (2020-08-01)

<i>Wikstroemia</i> <i>ganpi</i> Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice
by: Jonghwan Jegal, et al.
Published: (2021-04-01)

Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-<i>d</i>]pyrimidin-4(5<i>H</i>)-one Scaffold
by: Ana Dolšak, et al.
Published: (2021-03-01)

Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-<i>b</i>]Pyridine from a One-Pot Three-Component Reaction
by: Wei Lin, et al.
Published: (2019-08-01)

C4I SYSTEMS CONCEPT: DEFINITION AND DEVELOPMENTS
by: Constantin MINCU
Published: (2009-06-01)

The maintenance of cytochrome P4Ì²5Ì²0Ì²-related activity in rat hepatocytes in primary culture
by: Warren, M.
Published: (1988)

Natural Compounds and Their Structural Analogs in Regio- and Stereoselective Synthesis of New Families of Water-Soluble 2<i>H</i>,3<i>H</i>-[1,3]thia- and -Selenazolo[3,2-<i>a</i>]pyridin-4-ium Heterocycles by Annulation Reactions
by: Vladimir A. Potapov, et al.
Published: (2020-01-01)

Multiple <i>FGF4</i> Retrocopies Recently Derived within Canids
by: Kevin Batcher, et al.
Published: (2020-07-01)

LAPTM4B Down Regulation Inhibits the Proliferation, Invasion and Angiogenesis of HeLa Cells In Vitro
by: Fanling Meng, et al.
Published: (2015-09-01)

Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells
by: Chen Zhenguang, et al.
Published: (2012-02-01)

Identification of Yak’s <i>TLR4</i> Alternative Spliceosomes and Bioinformatic Analysis of TLR4 Protein Structure and Function
by: Xingdong Wang, et al.
Published: (2021-12-01)

First Report of CRISPR/Cas9 Mediated DNA-Free Editing of <i>4CL</i> and <i>RVE7</i> Genes in Chickpea Protoplasts
by: Sapna Badhan, et al.
Published: (2021-01-01)

Sas-4 Colocalizes with the Ciliary Rootlets of the <i>Drosophila</i> Sensory Organs
by: Veronica Persico, et al.
Published: (2021-01-01)

Vertical Orientation of Liquid Crystal on Comb-Like 4-(<i>trans</i>-4-alkylcyclohexyl)phenoxymethyl-substituted Polystyrene Containing Liquid Crystal Precursor
by: Kyutae Seo, et al.
Published: (2021-04-01)

DUX Hunting—Clinical Features and Diagnostic Challenges Associated with <i>DUX4</i>-Rearranged Leukaemia
by: Jacqueline A. Rehn, et al.
Published: (2020-09-01)

Characterization of <i>GLOD4</i> in Leydig Cells of Tibetan Sheep during Different Stages of Maturity
by: Xia Wang, et al.
Published: (2019-10-01)

<i>sxtA4+</i> and <i>sxtA4-</i> Genotypes Occur Together within Natural <i>Pyrodinium bahamense</i> Sub-Populations from the Western Atlantic
by: Kathleen Cusick, et al.
Published: (2021-05-01)

6-Nitro-7-tosylquinazolin-4(3<i>H</i>)-one
by: Thi Ngoc Nguyen, et al.
Published: (2020-11-01)

<i>CYP4F2</i> and <i>VKORC1</i> Polymorphisms Amplify the Risk of Carotid Plaque Formation
by: Stefan Cristian Vesa, et al.
Published: (2020-07-01)