PET and the multitracer concept in the study of neurodegenerative diseases

PET and the multitracer concept in the study of neurodegenerative diseases

ABSTRACT The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo,anatomopathological changes involved in the development of different clinic...

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Bibliographic Details
Main Authors: Henry Engler, Andres Damian, Cecilia Bentancourt
Format: Article
Language:English
Published: Associação Neurologia Cognitiva e do Comportamento
Series:Dementia & Neuropsychologia
Subjects:
PET
neurodegeneration
F-flourodeoxyglucose
PIB
Alzheimer's disease
Creutzfeldt-Jakob disease
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000400343&lng=en&tlng=en
Description
Summary:ABSTRACT The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo,anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of 18F-flourodeoxyglucose (FDG) and N-[11C-methyl]-L-deuterodeprenyl (DED), FDG and N-[11C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[11C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [15O]H2O.
ISSN:1980-5764

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