Use of 99m Tc in The Field of Radiofarmation: A Review
A B S T R A C T Technetium-99m ( 99m Tc) has been applied in nuclear medicine as a radiopharmacy for both diagnosis and therapy. 99m Tc is obtained from a 99 Mo/ 99m Tc (half-life 66 h) generator in the form of sodium pertechnetate (Na[ 99m TcO 4 ]) by decaying to 99 Tc for 6 hours and emitting gamm...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine Universitas Sriwijaya
2021-01-01
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| Series: | Biomedical Journal of Indonesia |
| Subjects: | |
| Online Access: | https://jurnalkedokteranunsri.id/index.php/BJI/article/view/241 |
| Summary: | A B S T R A C T
Technetium-99m ( 99m Tc) has been applied in nuclear medicine as a radiopharmacy
for both diagnosis and therapy. 99m Tc is obtained from a 99 Mo/ 99m Tc (half-life 66 h)
generator in the form of sodium pertechnetate (Na[ 99m TcO 4 ]) by decaying to 99 Tc for 6
hours and emitting gamma energy rays (Eɤ = 140 keV). This radionuclide has an
electron configuration of 4d 5 5s 2 , which will form complexes with different ligands
and have oxidation rates from +1 to +7. The coordinated complex of technetium-99m
has been utilized in nuclear medicine in tissues and organs (thyroid, red and white
blood cells, kidneys, brain, myocardial, and bone). The resulting kit production must
have based on Good Manufacturing Practice, which consists of batch planning,
washing, sterilization of glassware and stopper, starting material, preparation of
large quantities of the solution, sterile filtration, dispensing, crimping, a summary of
process control, quarantine, packaging and leaving the production premises. |
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| ISSN: | 2407-7097 2685-0184 |