The Effects of Prostodin and Hydroalcoholic Extract of Malvaneglecta on the Levels of Hepatic Enzymes and Factors and Its Histopathological Changes in Female Rats

• Main Authors: Amineh Beyrami Miavaghi, Farah Farokhi
• Format: Article
• Language: fas
• Published: Qom University of Medical Sciences 2015-03-01
• Series: Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
• Subjects: malvaneglecta; prostodin; liver; rats.
• Online Access: http://journal.muq.ac.ir/article-1-635-en.html

Background and Objectives:Prostodin is a chemical drug, which is often used for pregnancy termination. In traditional medicine, Malvaneglecta is used for abortion. In this study, the effects of hydroalcohlic extract of Malvaneglecta and prostodin on the liver tissue of female rats were investigated and compared. Methods: In this research, 24 female rats were randomly divided into 4 groups of 6 each as follows: The first group was considered as control, which received normal diet (food and water); the second group received extract of Malvaneglecta (at a dose of 200mg/kg.bw); the third group received extract of Malvaneglecta (500mg/kg.bw) orally; and the fourth group received prostodin (2mg/kg.bw) via intraperitoneal injection. After 18 days of treatment, the rats were anesthetized and their liver was removed for biochemical analysis after cupping. The prepared tissue sections were studied using light microscopy after H&E staining. Data were analyzed by one-way ANOVA and Tukey’s test. The significance level was considered p<0.05. Results: The serum levels of ALT, AST, LDL, triglyceride, and cholesterol significantly decreased (p<0.05) in the groups received Malvaneglecta and significantly increased in the group received prostodin, compared to the control group. Liver necrosis was observed in liver tissue sections from the group treated with prostodin, but no liver necrosis was observed in the groups treated with Malvaneglecta. Conclusion: According to the findings of this study, extract of Malvaneglecta, in contrast to prostodin, has protective effect and prevents hepatic necrosis without serious damage to the liver.