A Deep Learning Approach for Detecting Copy Number Variation in Next-Generation Sequencing Data

A Deep Learning Approach for Detecting Copy Number Variation in Next-Generation Sequencing Data

Copy number variants (CNV) are associated with phenotypic variation in several species. However, properly detecting changes in copy numbers of sequences remains a difficult problem, especially in lower quality or lower coverage next-generation sequencing data. Here, inspired by recent applications o...

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Bibliographic Details
Main Authors: Tom Hill, Robert L. Unckless
Format: Article
Language:English
Published: Oxford University Press 2019-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
coverage
deletion
duplication
machine-learning
next-generation sequencing
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400596

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