Study of Thermal Analysis Behavior of Fenbendazole and Rafoxanide

• Main Authors: Ali Kamal Attia, Ahmed Sayed Saad, Manal Sami Alaraki, Eman Saad Elzanfaly
• Format: Article
• Language: English
• Published: Tabriz University of Medical Sciences 2017-06-01
• Series: Advanced Pharmaceutical Bulletin
• Subjects: Fenbendazole; Rafoxanide; Thermal analysis; Purity; Molecular orbital calculations
• Online Access: http://journals.tbzmed.ac.ir/APB/Manuscript/APB-7-329.pdf

Purpose: Thermal analysis techniques have been applied to study the thermal behavior of fenbendazole (Fen) and rafoxanide (Raf). Semi-empirical molecular orbital calculations were used to confirm these results. Methods: Thermogravimetric analysis, derivative thermogravimetry, differential thermal analysis and differential scanning calorimetry were used to determine the thermal behavior and purity of the drugs under investigation. Results: Thermal behavior of Fen and Raf were augmented using semi-empirical molecular orbital calculations. The purity values were found to be 99.17% and 99.60% for Fen and Raf, respectively. Conclusion: Thermal analysis techniques gave satisfactory results to obtain quality control parameters such as melting point and degree of purity at low cost, furthermore, its simplicity and sensitivity justifies its application in quality control laboratories.