Metabolic Networks Influencing Skeletal Muscle Fiber Composition
Advancements in metabolomic and genomic research tools are revealing new insights into how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, we summarize the recent progress of metabolite-dependent signaling pathways and transcriptional regulators that control...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-09-01
|
Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2018.00125/full |
id |
doaj-ba3ebb0bbf534b0a95eff8daac1c45c0 |
---|---|
record_format |
Article |
spelling |
doaj-ba3ebb0bbf534b0a95eff8daac1c45c02020-11-24T21:54:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-09-01610.3389/fcell.2018.00125408943Metabolic Networks Influencing Skeletal Muscle Fiber CompositionIsabelle Bourdeau Julien0Isabelle Bourdeau Julien1Chantelle F. Sephton2Chantelle F. Sephton3Paul A. Dutchak4Paul A. Dutchak5Department of Psychiatry and Neuroscience, Université Laval, Quebec, QC, CanadaCERVO Brain Research Centre, Quebec, QC, CanadaDepartment of Psychiatry and Neuroscience, Université Laval, Quebec, QC, CanadaCERVO Brain Research Centre, Quebec, QC, CanadaDepartment of Psychiatry and Neuroscience, Université Laval, Quebec, QC, CanadaCERVO Brain Research Centre, Quebec, QC, CanadaAdvancements in metabolomic and genomic research tools are revealing new insights into how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, we summarize the recent progress of metabolite-dependent signaling pathways and transcriptional regulators that control glycolytic and oxidative metabolism and ultimately influence the type of fibers in muscle depots. These mechanisms expand the role of metabolites beyond that of basic building blocks of cellular components, and illustrate how particular metabolites can take an active role in regulating metabolic homeostasis and fiber adaptation. As new metabolite-dependent mechanisms emerge, ongoing metabolomic studies have begun to help explain why distinct metabolic pathways are used in different biological contexts and widen the view of seminal observations like the Warburg effect.https://www.frontiersin.org/article/10.3389/fcell.2018.00125/fullmTORC1GATOR1nuclear hormone receptor (NHR)metabolismwarbug effectmuscle physiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isabelle Bourdeau Julien Isabelle Bourdeau Julien Chantelle F. Sephton Chantelle F. Sephton Paul A. Dutchak Paul A. Dutchak |
spellingShingle |
Isabelle Bourdeau Julien Isabelle Bourdeau Julien Chantelle F. Sephton Chantelle F. Sephton Paul A. Dutchak Paul A. Dutchak Metabolic Networks Influencing Skeletal Muscle Fiber Composition Frontiers in Cell and Developmental Biology mTORC1 GATOR1 nuclear hormone receptor (NHR) metabolism warbug effect muscle physiology |
author_facet |
Isabelle Bourdeau Julien Isabelle Bourdeau Julien Chantelle F. Sephton Chantelle F. Sephton Paul A. Dutchak Paul A. Dutchak |
author_sort |
Isabelle Bourdeau Julien |
title |
Metabolic Networks Influencing Skeletal Muscle Fiber Composition |
title_short |
Metabolic Networks Influencing Skeletal Muscle Fiber Composition |
title_full |
Metabolic Networks Influencing Skeletal Muscle Fiber Composition |
title_fullStr |
Metabolic Networks Influencing Skeletal Muscle Fiber Composition |
title_full_unstemmed |
Metabolic Networks Influencing Skeletal Muscle Fiber Composition |
title_sort |
metabolic networks influencing skeletal muscle fiber composition |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2018-09-01 |
description |
Advancements in metabolomic and genomic research tools are revealing new insights into how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, we summarize the recent progress of metabolite-dependent signaling pathways and transcriptional regulators that control glycolytic and oxidative metabolism and ultimately influence the type of fibers in muscle depots. These mechanisms expand the role of metabolites beyond that of basic building blocks of cellular components, and illustrate how particular metabolites can take an active role in regulating metabolic homeostasis and fiber adaptation. As new metabolite-dependent mechanisms emerge, ongoing metabolomic studies have begun to help explain why distinct metabolic pathways are used in different biological contexts and widen the view of seminal observations like the Warburg effect. |
topic |
mTORC1 GATOR1 nuclear hormone receptor (NHR) metabolism warbug effect muscle physiology |
url |
https://www.frontiersin.org/article/10.3389/fcell.2018.00125/full |
work_keys_str_mv |
AT isabellebourdeaujulien metabolicnetworksinfluencingskeletalmusclefibercomposition AT isabellebourdeaujulien metabolicnetworksinfluencingskeletalmusclefibercomposition AT chantellefsephton metabolicnetworksinfluencingskeletalmusclefibercomposition AT chantellefsephton metabolicnetworksinfluencingskeletalmusclefibercomposition AT pauladutchak metabolicnetworksinfluencingskeletalmusclefibercomposition AT pauladutchak metabolicnetworksinfluencingskeletalmusclefibercomposition |
_version_ |
1725864914032001024 |