Metabolic Networks Influencing Skeletal Muscle Fiber Composition

Advancements in metabolomic and genomic research tools are revealing new insights into how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, we summarize the recent progress of metabolite-dependent signaling pathways and transcriptional regulators that control...

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Main Authors: Isabelle Bourdeau Julien, Chantelle F. Sephton, Paul A. Dutchak
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00125/full
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spelling doaj-ba3ebb0bbf534b0a95eff8daac1c45c02020-11-24T21:54:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-09-01610.3389/fcell.2018.00125408943Metabolic Networks Influencing Skeletal Muscle Fiber CompositionIsabelle Bourdeau Julien0Isabelle Bourdeau Julien1Chantelle F. Sephton2Chantelle F. Sephton3Paul A. Dutchak4Paul A. Dutchak5Department of Psychiatry and Neuroscience, Université Laval, Quebec, QC, CanadaCERVO Brain Research Centre, Quebec, QC, CanadaDepartment of Psychiatry and Neuroscience, Université Laval, Quebec, QC, CanadaCERVO Brain Research Centre, Quebec, QC, CanadaDepartment of Psychiatry and Neuroscience, Université Laval, Quebec, QC, CanadaCERVO Brain Research Centre, Quebec, QC, CanadaAdvancements in metabolomic and genomic research tools are revealing new insights into how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, we summarize the recent progress of metabolite-dependent signaling pathways and transcriptional regulators that control glycolytic and oxidative metabolism and ultimately influence the type of fibers in muscle depots. These mechanisms expand the role of metabolites beyond that of basic building blocks of cellular components, and illustrate how particular metabolites can take an active role in regulating metabolic homeostasis and fiber adaptation. As new metabolite-dependent mechanisms emerge, ongoing metabolomic studies have begun to help explain why distinct metabolic pathways are used in different biological contexts and widen the view of seminal observations like the Warburg effect.https://www.frontiersin.org/article/10.3389/fcell.2018.00125/fullmTORC1GATOR1nuclear hormone receptor (NHR)metabolismwarbug effectmuscle physiology
collection DOAJ
language English
format Article
sources DOAJ
author Isabelle Bourdeau Julien
Isabelle Bourdeau Julien
Chantelle F. Sephton
Chantelle F. Sephton
Paul A. Dutchak
Paul A. Dutchak
spellingShingle Isabelle Bourdeau Julien
Isabelle Bourdeau Julien
Chantelle F. Sephton
Chantelle F. Sephton
Paul A. Dutchak
Paul A. Dutchak
Metabolic Networks Influencing Skeletal Muscle Fiber Composition
Frontiers in Cell and Developmental Biology
mTORC1
GATOR1
nuclear hormone receptor (NHR)
metabolism
warbug effect
muscle physiology
author_facet Isabelle Bourdeau Julien
Isabelle Bourdeau Julien
Chantelle F. Sephton
Chantelle F. Sephton
Paul A. Dutchak
Paul A. Dutchak
author_sort Isabelle Bourdeau Julien
title Metabolic Networks Influencing Skeletal Muscle Fiber Composition
title_short Metabolic Networks Influencing Skeletal Muscle Fiber Composition
title_full Metabolic Networks Influencing Skeletal Muscle Fiber Composition
title_fullStr Metabolic Networks Influencing Skeletal Muscle Fiber Composition
title_full_unstemmed Metabolic Networks Influencing Skeletal Muscle Fiber Composition
title_sort metabolic networks influencing skeletal muscle fiber composition
publisher Frontiers Media S.A.
series Frontiers in Cell and Developmental Biology
issn 2296-634X
publishDate 2018-09-01
description Advancements in metabolomic and genomic research tools are revealing new insights into how metabolic networks can influence skeletal muscle fiber composition. In this mini-review, we summarize the recent progress of metabolite-dependent signaling pathways and transcriptional regulators that control glycolytic and oxidative metabolism and ultimately influence the type of fibers in muscle depots. These mechanisms expand the role of metabolites beyond that of basic building blocks of cellular components, and illustrate how particular metabolites can take an active role in regulating metabolic homeostasis and fiber adaptation. As new metabolite-dependent mechanisms emerge, ongoing metabolomic studies have begun to help explain why distinct metabolic pathways are used in different biological contexts and widen the view of seminal observations like the Warburg effect.
topic mTORC1
GATOR1
nuclear hormone receptor (NHR)
metabolism
warbug effect
muscle physiology
url https://www.frontiersin.org/article/10.3389/fcell.2018.00125/full
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