gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). MicroRNAs (miRNAs) are involved in host-pathogen interactions and innate immune response to viral infection. However, the role of miRNAs in host response to IBDV infection...
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fcimb.2018.00055/full |
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doaj-ba3cd015a2b64252b8c1100a329493252020-11-24T22:43:22ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882018-03-01810.3389/fcimb.2018.00055331244gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANKBin Wang0Bin Wang1Bin Wang2Mengjiao Fu3Mengjiao Fu4Mengjiao Fu5Yanan Liu6Yanan Liu7Yanan Liu8Yongqiang Wang9Yongqiang Wang10Yongqiang Wang11Xiaoqi Li12Hong Cao13Hong Cao14Hong Cao15Shijun J. Zheng16Shijun J. Zheng17Shijun J. Zheng18State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, ChinaKey Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaState Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, ChinaKey Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaState Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, ChinaKey Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaState Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, ChinaKey Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaState Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, ChinaKey Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaState Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, ChinaKey Laboratory of Animal Epidemiology of the Ministry of Agriculture, China Agricultural University, Beijing, ChinaDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaInfectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). MicroRNAs (miRNAs) are involved in host-pathogen interactions and innate immune response to viral infection. However, the role of miRNAs in host response to IBDV infection is not clear. We report here that gga-miR-155 acts as an anti-virus host factor inhibiting IBDV replication. We found that transfection of DF-1 cells with gga-miR-155 suppressed IBDV replication, while blockage of the endogenous gga-miR-155 by inhibitors enhanced IBDV replication. Furthermore, our data showed that gga-miR-155 enhanced the expression of type I interferon in DF-1 cells post IBDV infection. Importantly, we found that gga-miR-155 enhanced type I interferon expression via targeting SOCS1 and TANK, two negative regulators of type I IFN signaling. These results indicate that gga-miR-155 plays a critical role in cell response to IBDV infection.http://journal.frontiersin.org/article/10.3389/fcimb.2018.00055/fullmicroRNAtype I IFNIBDVSOCSTANK |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Bin Wang Bin Wang Bin Wang Mengjiao Fu Mengjiao Fu Mengjiao Fu Yanan Liu Yanan Liu Yanan Liu Yongqiang Wang Yongqiang Wang Yongqiang Wang Xiaoqi Li Hong Cao Hong Cao Hong Cao Shijun J. Zheng Shijun J. Zheng Shijun J. Zheng |
| spellingShingle |
Bin Wang Bin Wang Bin Wang Mengjiao Fu Mengjiao Fu Mengjiao Fu Yanan Liu Yanan Liu Yanan Liu Yongqiang Wang Yongqiang Wang Yongqiang Wang Xiaoqi Li Hong Cao Hong Cao Hong Cao Shijun J. Zheng Shijun J. Zheng Shijun J. Zheng gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK Frontiers in Cellular and Infection Microbiology microRNA type I IFN IBDV SOCS TANK |
| author_facet |
Bin Wang Bin Wang Bin Wang Mengjiao Fu Mengjiao Fu Mengjiao Fu Yanan Liu Yanan Liu Yanan Liu Yongqiang Wang Yongqiang Wang Yongqiang Wang Xiaoqi Li Hong Cao Hong Cao Hong Cao Shijun J. Zheng Shijun J. Zheng Shijun J. Zheng |
| author_sort |
Bin Wang |
| title |
gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK |
| title_short |
gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK |
| title_full |
gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK |
| title_fullStr |
gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK |
| title_full_unstemmed |
gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK |
| title_sort |
gga-mir-155 enhances type i interferon expression and suppresses infectious burse disease virus replication via targeting socs1 and tank |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cellular and Infection Microbiology |
| issn |
2235-2988 |
| publishDate |
2018-03-01 |
| description |
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). MicroRNAs (miRNAs) are involved in host-pathogen interactions and innate immune response to viral infection. However, the role of miRNAs in host response to IBDV infection is not clear. We report here that gga-miR-155 acts as an anti-virus host factor inhibiting IBDV replication. We found that transfection of DF-1 cells with gga-miR-155 suppressed IBDV replication, while blockage of the endogenous gga-miR-155 by inhibitors enhanced IBDV replication. Furthermore, our data showed that gga-miR-155 enhanced the expression of type I interferon in DF-1 cells post IBDV infection. Importantly, we found that gga-miR-155 enhanced type I interferon expression via targeting SOCS1 and TANK, two negative regulators of type I IFN signaling. These results indicate that gga-miR-155 plays a critical role in cell response to IBDV infection. |
| topic |
microRNA type I IFN IBDV SOCS TANK |
| url |
http://journal.frontiersin.org/article/10.3389/fcimb.2018.00055/full |
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