Conditional IL-2 gene deletion: consequences for T cell proliferation

Conditional IL-2 gene deletion: consequences for T cell proliferation

To explore the role of interleukin-2 (IL-2) in T cell proliferation, and to circumvent the IL-2 deficiency autoimmune syndrome of conventional il2 gene deletion, mice were created to allow conditional il2 gene deletion when treated with the estrogen analogue, tamoxifen (TAM) as adults. Splenocytes f...

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Bibliographic Details
Main Authors: Kendall A Smith, Zoran ePopmihajlov, Dong eXu, Heather eMorgan, Zoie eMilligan
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Immunology
Subjects:
Interleukin-2
lymphocyte blastic transformation
T cell proliferation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00102/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00102/full

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