Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity

Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity

NMDA receptor (NMDAR) antagonists, such as phencyclidine, ketamine or dizocilpine (MK-801) are commonly used in psychiatric drug discovery in order to model several symptoms of schizophrenia, including psychosis and impairments in working memory. In spite of the widespread use of NMDAR antagonists...

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Bibliographic Details
Main Authors: Tamás eKiss, William E Hoffmann, Liam eScott, Thomas T Kawabe, Anthony J Milici, Erik A Nilsen, Mihály eHajós
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-04-01
Series:Frontiers in Psychiatry
Subjects:
Schizophrenia
local field potential
Medial prefrontal cortex
subiculum
localized drug microinjection
MK-801
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2011.00014/full

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