Effect of sublingual immunotherapy combined with Loratadine on blood parameters and induced sputum indicators in children with allergic rhinitis

• Main Authors: Ling He, Zhi-Jin Lin
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-05-01
• Series: Journal of Hainan Medical University
• Subjects: Allergic rhinitis; Sublingual immunotherapy; Loratadine; Induced sputum
• Online Access: http://www.hnykdxxb.com/PDF/201610/26.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To analyze the effect of sublingual immunotherapy combined with Loratadine on blood parameters and induced sputum indicators in children with allergic rhinitis. Methods: A total of 172 cases of children with allergic rhinitis treated in our hospital from August 2012 to November 2014 were selected as research subjects and randomly divided into observation group 86 cases and control group 86 cases according to different treatment methods. Control group received Loratadine therapy alone, observation group received sublingual immunotherapy combined with Loratadine, and then differences in EOS count, lymphocyte subset levels, serum inflammation-related factor levels and growth factor levels in induced sputum between two groups were compared. Results: Eos count values of observation group at all times after treatment were lower than those of control group; CD3-CD19+, CD8+ and CD8+CD28- levels of observation group after treatment were lower than those of control group, and CD8+CD28+ and CD28+ levels were higher than those of control group; IL-4 and IL-17 levels of observation group after treatment were lower than those of control group, and IL-10, IL-35 and IFN-γ levels were higher than those of control group; EGF, PDGF-BB and TGF-β1 levels of observation group after treatment were higher than those of control group, and PDGF-AA, bFGF and VEGF levels were lower than those of control group. Conclusion: Sublingual immunotherapy combined with Loratadine therapy for children with allergic rhinitis can effectively optimize body’s immune status and restore microenvironment homeostasis, and it has active clinical significance.