Fabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy

• Main Authors: Liao W, Zhang L, Zhong Y, Shen Y, Li C, An N
• Format: Article
• Language: English
• Published: Dove Medical Press 2018-04-01
• Series: OncoTargets and Therapy
• Subjects: Periodic mesoporous organosilica; WS2 quantum dots; chemo-photothermal therapy; drug delivery
• Online Access: https://www.dovepress.com/fabrication-of-ultrasmall-ws2-quantum-dots-coated-periodic-mesoporous--peer-reviewed-article-OTT

Wenyun Liao,1 Li Zhang,1 Yunhua Zhong,2 Yuan Shen,1 Changlin Li,1 Na An1 1Department of Emergency, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, People’s Republic of China; 2Department of Geriatrics, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, People’s Republic of China Introduction: The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS2 quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas (PMOs-DOX@WQDs) nanoparticles were fabricated for the first time, and which exhibits good potential for synergistic chemo-photothermal therapy.Materials and methods: The structure, light-mediated drug release behavior, photothermal effect, and synergistic therapeutic efficiency of PMOs-DOX@WQDs to HCT-116 colon cancer cells were investigated. The thioether-bridged PMOs exhibit a high DOX loading capacity of 66.7 µg mg−1. The gating of the PMOs not only improve the drug loading capacity but also introduce the dual-stimuli-responsive performance. Furthermore, the as-synthesized PMOs-DOX@WQDs nanoparticles can efficiently generate heat to the hyperthermia temperature with near infrared laser irradiation.Results: It was confirmed that PMOs-DOX@WQDs exhibit remarkable photothermal effect and light-triggered faster release of DOX. More importantly, it was reasonable to attribute the efficient anti-tumor efficiency of [e-mail]: The in vitro experimental results confirm that the fabricated nanocarrier exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the WQD-coated PMOs present promising applications in cancer therapy. Keywords: periodic mesoporous organosilica, WS2 quantum dots, chemo-photothermal therapy, drug delivery