Engineering calcium signaling of astrocytes for neural–molecular computing logic gates

Abstract This paper proposes the use of astrocytes to realize Boolean logic gates, through manipulation of the threshold of $$\hbox {Ca}^{2+}$$ Ca 2 + ion flows between the cells based on the input signals. Through wet-lab experiments that engineer the astrocytes cells with pcDNA3.1-hGPR17 genes as...

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Bibliographic Details
Main Authors: Michael Taynnan Barros, Phuong Doan, Meenakshisundaram Kandhavelu, Brendan Jennings, Sasitharan Balasubramaniam
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79891-x